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Synthetic bedding and wheeze in childhood.
合成纖維寢具與童年時期的氣喘

Ponsonby AL, Dwyer T, Kemp A, Cochrane J, Couper D, Carmichael A.

National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia. anne-louise.ponsonby@anu.edu.au

BACKGROUND: The reasons for the increase in childhood asthma over time are unclear. The indoor environment is of particular concern.。An adverse role for synthetic bedding on asthma development in childhood has been suggested by cross-sectional studies that have found an association between synthetic pillow use and childhood wheeze. Prospective data on infant bedding have not been available.

背景：提高兒童氣喘可能性至今仍不清楚。室內環境是主要的考量因素除此之外，許多代表性的研究報告發現到合成纖維製的枕頭的使用和兒童氣喘之間的關連，推斷合成纖維(人造纖維)寢具是另一項可能導致孩童氣喘的成因。至於嬰兒寢具的影響目前還沒有資料可以參考。

METHODS: Bedding data at 1 month of age were available from an infant survey for children who were participating in a 1995 follow-up study (N = 863; 78% traced).
The 1995 follow-up was embedded in a larger cross-sectional survey involving 6,378 seven year olds in Tasmania (N = 92% of eligible). Outcome measures included respiratory symptoms as defined in the International Study of Asthma and Allergies in Childhood protocol. Frequent wheeze was defined as more than 12 wheeze episodes over the past year compared with no wheeze.

方式：參加1995年後續研究訪問的孩童可從新生兒問卷中取得一個月大的嬰兒所使用的寢具資料 (N = 863; 78%追蹤) 。 1995年的後續訪是一項大型代表性的研究調查，受訪對向適塔斯梅尼亞島上（位於澳洲東南方）的6378位七歲孩童(N = 92%通過資格)。審查資格的方式包括呼吸系統符合「國際氣喘與過敏研究之兒童議定書」的內容，另一項為「經常性哮喘」。「經常性哮喘」則定義為，在過去一年內有發生超過12次的氣喘經驗者。

RESULTS: Synthetic pillow use at 1 month of age was associated with frequent wheeze at age 7 (adjusted relative risk [aRR] = 2.5; 95% confidence interval [CI] = 1.2-5.5) independent of childhood exposure. Current synthetic pillow and quilt use was strongly associated with frequent wheeze (aRR = 5.2; CI = 1.3-20.6). Substantial trends were evident for an association of increasing number of synthetic bedding items with frequent wheeze and with increasing wheeze frequency. Among children with asthma, the age of onset of asthma occurred earlier if synthetic bedding was used in infancy.

結果：嬰兒在一個月大時使用合成纖維枕頭，在七歲時患有哮喘有關連（校正相對危險[aRR] = 2.5; 95% 置信區間[CI] = 1.2-5.5）。目前市場上的合成纖維枕頭和被褥都與經常性哮喘有著密不可分的關係（aRR = 5.2; CI = 1.3-20.6）。大量的研究走向都可以證明，使用合成纖維寢具項目的多寡，與經常性哮喘，甚至惡化其症狀有關。患有氣喘的孩童，若在嬰兒時期救使用合成纖維寢具，首次發病的時間也會跟著提早。

CONCLUSIONS: In this cohort, synthetic bedding was strongly and consistently associated with frequent childhood wheeze. The association did not appear to be attributable to bedding choice as part of an asthma management strategy.

結論：這群受訪孩童，使用合成纖維寢具的確強大地持續地關係到他們經常性的氣喘現象。但這項關連尚未被歸因寢具的選擇而作為氣喘管理策略的一部分。

PMID: 12500044 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/12500044